<p>At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.</p> <p>Come join the rapidly expanding Lilly Gene Therapy team at Eli Lilly! We are responsible for inventing, characterizing, and advancing novel genome therapy reagents for a myriad of clinical applications. Our team works cross-functionally within our organization across multiple disease areas and platforms. Our goal is to deliver on the promise of gene therapy to patients around the world.</p> <p>Job Responsibilities:</p> <p>The Scientist, Early Preclinical Development, will participate and contribute to the in-vivo pharmacology lab to support the discovery and optimization of novel therapeutic candidates for Gene Therapy. As part of the Early Preclinical Development team, s/he will be a key driver to advance novel targets for neurodegenerative disorders, as well as exploring AAV biodistribution.</p> <ul> <li>Conduct in vivo pharmacology experiments and studies to characterize activity of gene therapy vectors in animal models using various histologic methods </li><li>Perform in-vivo and organ sampling to support various cross-functional teams </li><li>Assist in the development and characterization of novel animal models using various histologic read outs </li><li>Collaborate with cross-functional partners (e.g., Target Discovery, Translational, and CROs) to help ensure translation of candidates from discovery to development </li><li>Perform studies to investigate the in vivo distribution of AAV by imaging modalities (e.g. In situ hybridization, immunohistochemistry, IVIS) </li><li>Keep and maintain accurate and timely documentation of all practical work: completion of electronic notebook in alignment with Lilly procedure quality standards and Good Documentation Practices </li><li>Weekend work may be required at times </li></ul> <p>Basic Qualifications:</p> <ul> <li>Bachelors and/or Master's degree in life sciences (e.g., biology, neuroscience, or related scientific field) with 1+ years of experience working in pharmaceutical industry, contract research organization, or academic setting. </li></ul> <p>Additional Skills/Preferences:</p> <ul> <li>Experience in rodent handling, including dosing (iv, ip, po, etc) and harvesting tissues/fluids </li><li>Experience with ex-vivo assays is a plus such as ELISAs, WB, qPCR, and histology techniques </li><li>Experience in cell culture is desired </li><li>Passion, knowledge and experience in neuroscience or rare disease research </li><li>Strong analytic thinking skills. Demonstrated ability to articulate issues, and extract and synthesize complex issues into key focus. </li><li>Creative and curious. Can quickly adapt in a fast-paced working environment </li><li>Strong interpersonal and communication skills. Proven record to collaborate and network across a wide variety of functions and work effectively with internal and external partners. </li></ul> <p>Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.</p> <p>Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.</p> <p>Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.</p> <p>Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is</p> <p>$69,000 - $179,300</p> <p>Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.</p> <p>#WeAreLilly</p>