<ul> <li>Job title Experienced Scientist, Viral Vector Downstream Process </li><li>Function Discovery & Pre-Clinical/Clinical Development </li><li>Sub function Biotherapeutics R&D </li><li>Category Experienced Scientist, Biotherapeutics R&D (ST5) </li><li>Location Spring House / United States of America </li><li>Date posted Jun 26 2025 </li><li>Requisition number R-020256 </li><li>Work pattern Fully Onsite </li></ul> <p>Description</p> <p>At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com</p> <p>Job Function:</p> <p>Discovery & Pre-Clinical/Clinical Development</p> <p>Job Sub Function:</p> <p>Biotherapeutics R&D</p> <p>Job Category:</p> <p>Scientific/Technology</p> <p>All Job Posting Locations:</p> <p>Spring House, Pennsylvania, United States of America</p> <p>Job Description:</p> <p>About Innovative Medicine</p> <p>Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.</p> <p>Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.</p> <p>Learn more at https://www.jnj.com/innovative-medicine</p> <p>We are searching for the best talent for an Experienced Scientist, Viral Vector Downstream Process to be located in Spring House, PA.</p> <p>Purpose:</p> <p>The Experienced Scientist, Viral Vector Downstream Process position in the Cell Therapy Platform & Discovery group of Therapeutics Discovery offers an exciting opportunity to help develop novel Cell & Gene Therapies for unmet medical needs. We are investigating the use of engineered viral vectors for ex vivo and in vivo gene delivery to T cells to treat cancer. We are seeking a highly motivated downstream process scientist to develop and implement vector purification strategies to enable preclinical studies. Do you have industry experience with downstream viral vector process development and the ability to thrive in a cross-functional team? Come join us in our mission to build the next generation of Cell & Gene Therapies for Oncology.</p> <p>You will be responsible for:</p> <ul> <li>Design, optimize, and execute downstream purification processes to improve yield, purity, and stability of lentiviral vectors (LVV) </li><li>Independently operate and maintain chromatography and filtration systems (e.g., TFF, depth filtration) for virus purification </li><li>Collaborate with stakeholders to ensure timely delivery of purified, quality-controlled vector lots to support preclinical studies </li><li>Maintain detailed records for vector productions and process development experiments to ensure traceability and data integrity </li><li>Contribute to a collaborative, creative, and rigorous culture of scientific discovery </li></ul> <p>Qualifications:</p> <ul> <li>BS or MS in Biological Engineering, Chemical Engineering, Virology, Biology, or related field with 2+ years of related experience is required. Industry experience is preferred. </li><li>Experience with viral vector downstream processing methods, including column chromatography (Akta), is required </li><li>Expertise in LVV purification is preferred </li><li>Familiarity with analytical techniques for lentiviral vectors is preferred </li><li>Strong critical, scientific, and strategic thinking skills are required </li><li>Strong organizational skills, with the ability to independently manage multiple projects in parallel, are required </li><li>Demonstrated ability to work collaboratively in cross-functional teams is required </li><li>This role may require up to 5-10% travel. </li></ul> <p>Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.</p> <p>Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (ra-employeehealthsup@its.jnj.com) or contact AskGS to be directed to your accommodation resource.</p> <p>#LI-Onsite</p>