<p>What You Will Contribute To Altos</p> <p>As a Structural Biology Senior Scientist at Altos Labs, you will be at the forefront of innovative research in understanding the molecular mechanisms of disease with a focus on aging and rejuvenation. Your role will involve leading the protein biochemistry and structural biology function within the Institute of Medicine and applying these techniques to support our large- and small-molecule drug discovery portfolio. In addition, you will contribute to a strong culture of trust and teamwork, modelling the Altos Labs behaviors.</p> <p>Responsibilities</p> <ul> <li>Lead experimental structural biology and protein biochemistry within the Institute of Medicine </li><li>Develop and execute structural biology strategies (expression system, purification, structure determination method, etc.) to advance the Altos discovery portfolio from early target validation through lead optimization </li><li>Collaborate with our in-house cryoEM core facility and CRO-based crystallographic facilities to deliver high-impact macromolecular structures </li><li>Work collaboratively with cross-functional scientists to enable structure-based design on discovery programs across different modalities </li><li>Represent structural biology and protein biochemistry on cross-functional project teams, and contribute to building and progressing the pipeline </li><li>Manage external research activities conducted by CROs and collaborators </li><li>Mentor and supervise junior scientists and technicians </li></ul> <p>Who You Are</p> <p>Minimum Qualifications</p> <ul> <li>PhD in Structural Biology, Biochemistry, Biophysics, or a related discipline </li><li>6+ years of experience in biotech or the pharmaceutical industry supporting structural biology efforts in large- or small-molecule drug discovery programs </li><li>Proven track record of high-resolution structure determination using X-ray crystallography or cryoEM </li><li>Strong publication record demonstrating expertise in structural biology </li><li>Experience managing external CRO activities supporting protein production, X-ray crystallography, and cryoEM structure determination. </li><li>Strong leadership, collaboration, and communication skills </li></ul> <p>Preferred Qualifications</p> <ul> <li>Demonstrated expertise in protein engineering or structure-guided protein design </li><li>Familiarity with structure-based drug design workflows and collaboration with medicinal/computational chemistry groups </li><li>Experience developing strategy for structurally intractable targets </li><li>Experience using structure prediction tools (e.g., AlphaFold, RosettaFold, Boltz) in an applied drug discovery setting </li><li>Ability to communicate the nuances of protein biochemistry to non-specialist stakeholders and executive leadership, ensuring alignment on project milestones </li><li>Experience in people management </li></ul> <p>The salary range for Redwood City, CA:</p> <ul> <li>Senior Scientist I, Structural Biology: $172,400 - $221,000 </li></ul> <p>Exact compensation may vary based on skills, experience, and location.</p> <p>#LI-NN1</p> <p>For UK applicants, before submitting your application:</p> <ul> <li>Please click here to read the Altos Labs EU and UK Applicant Privacy Notice (bit.ly/eu_uk_privacy_notice) </li><li>This Privacy Notice is not a contract, express or implied and it does not set terms or conditions of employment. </li></ul>