<p>Computational Biochemistry Internship</p> <p>About Edgewise Therapeutics:</p> <p>At Edgewise, we are on a mission to discover new medicines that improve the lives of patients facing serious muscle disease. Our intimate knowledge of muscle biology and biophysics along with our ability to identify and design muscle specific precision small molecules have enabled us to rapidly advance our skeletal muscle and cardiac muscle product candidates into the clinic while also building a robust pre-clinical pipeline. With this focus on therapeutics designed to protect and improve muscle health, our goal is to dramatically enhance the lives of people living with progressive muscle disorders.</p> <p>We have assembled an experienced and highly motivated leadership team with a strong track record in the biotechnology and pharmaceutical industry to build the leading, global muscle disease biopharmaceutical company. Come join us make a significant difference in the lives of patients!</p> <p>About the Position:</p> <p>The Computational Biochemistry Intern will work on specific projects such as:</p> <ul> <li>Protein isoform analysis from a sequence and structure perspective </li><li>Validation of predictions using internal and external datasets </li><li>Literature analysis of protein comparators from crystallographic sources </li><li>Prediction validation and analysis of closely related motifs </li></ul> <p>Essential Job Duties and Functions:</p> <ul> <li>Assist in the design and execution of in silico experiments </li><li>Analyze data using scientific software </li><li>Conduct literature reviews </li><li>Participate in team meetings and present findings </li></ul> <p>Required Education, Experience and Skills:</p> <ul> <li> <p>General</p> </li><li> <p>Familiarity with protein modeling software like AlphaFold2 or RoseTTAFold</p> </li><li> <p>Familiarity with proteomic sequence analysis and interpretation.</p> </li><li> <p>Strong organizational and communication skills</p> </li><li> <p>Ability to work independently and as part of a team</p> </li><li> <p>Specific education requirements</p> </li><li> <p>Course work: biology, physiology, anatomy, chemistry -or- biomedical engineering</p> </li><li> <p>Preferred</p> </li><li> <p>Basic understanding of muscle biology.</p> </li><li> <p>Docking simulation work</p> </li><li> <p>Foldseek, Fragfold experience</p> </li><li> <p>Desired qualifications of the student intern</p> </li><li> <p>Currently enrolled in a Bachelor's or Master's program in biology, physiology, pharmacology, biomedical science, or related field</p> </li><li> <p>Basic understanding of biology, physiology, anatomy, pharmacology, or biomedical science</p> </li></ul> <p>Salary range: $20/hour; internship runs for 8-10 weeks</p> <p>There is no deadline because the employer accepts applications on an ongoing basis.</p> <p>Edgewise does not accept resumes from recruitment agencies for this position. Please do not send resumes to Edgewise employees or the company location. Edgewise is not responsible for any fees related to unsolicited resumes.</p>