<p>Basic Qualifications</p> <p>Minimum of MS in Biological/ Pharmaceutical Sciences or a related field with at least 7 years of hands-on experience in academic or pharmaceutical/biotechnology labs.</p> <p>Additional Information</p> <p>This is a six month term position.</p> <p>All formal offers will be made by FAS Human Resources</p> <p>We are unable to provide visa sponsorship for this position.</p> <p>This position is included within the Harvard Academic Workers (HAW) union.</p> <p>Position Description</p> <p>Independently lead and execute large-scale small molecule screens for hit identification and contribute to follow-up experiments throughout medicinal chemistry and lead optimization.</p> <ul> <li>Lead the development of assays for small molecule discovery </li><li>Miniaturize and adapt cell-based and biochemical assays to automated screening systems </li><li>Propose and develop innovative approaches to small molecule discovery based on the latest technologies and publications in the field </li><li>Analyze, critically interpret and present data to industry partners, and recommend courses of action based on datasets and discussions with biologists and chemists. </li></ul> <p>Work with multi-scientist team to develop subcutaneous organoid with appropriate signaling molecules to improve t-cell reconstitution.</p> <ul> <li>Develop protocols to achieve reproducible organoids for large scale work in mice, humanized mice, and higher order species. </li><li>Develop protocols to analyze T-cell recovery in higher order species </li><li>Explore additional molecules to improve stem cell content in subcutaneous organoids to serve as a means to improve gene therapy induction in HSCs. </li></ul> <p>Job Summary</p> <p>The Scadden laboratory is dedicated to discovering the principles governing blood cell production, with the ultimate goal of guiding the development of therapies for blood disorders and cancer. The Lab is seeking an experienced scientist to provide scientific and administrative leadership for three projects. The Research scientist will collaborate with the Principal Investigator to develop and execute complex and specialized research studies as part of an industry-sponsored collaboration. They will also collaborate with and manage other scientists recruited to work on the project.</p>