<p>Overview</p> <p>Monte Rosa Therapeutics is seeking a motivated HighThroughput Ceelular Assasy expert to contribute to our mission of eliminating disease-causing proteins through targeted protein degradation, an innovative approach that enables us to target proteins once considered undruggable. The ideal candidate will have strong expertise in developing high-throughput cellular assays for screening and compound profiling. You will join a fast-paced and innovative team environment that values teamwork, collaboration, and scientific rigor.</p> <p>Responsibilities</p> <ul> <li>Culture a variety of cell lines and primary cells to develop and optimize high-throughput cellular assays to evaluate target engagement, degradation and pathway modulation </li><li>Utilize automation system to execute cell-based screening and profiling campaigns </li><li>Collaborate within a matrixed environment that integrates multiple functions to drive program decisions. </li><li>Keep meticulous records of experiments on ELN. </li></ul> <p>Qualifications</p> <ul> <li>MS or Ph.D. with in Molecular Biology, Biochemistry, Biology, or related field. </li><li>The Senior Research Associate II level will have 4-6 years of relevent industrial experience and a Scientist wiill pocess 1-2 years industrial exerience </li><li>A thorough understanding of assay principles is required </li><li>Hands-on experience developing and executing cellular assays for lead discovery and optimization is required. Relevant assay formats include NanoBRET, cellular HTRF, AlphaLISA, HiBiT, and NanoBiT, Degradation Kinetics. </li><li>Experience working in a drug discovery environment is preferred. </li><li>Experience with compound screening formats, laboratory instrumentation and automation, data analysis and management is preferred. </li><li>Strong collaborative mindset with the ability to thrive in a team-oriented setting. </li><li>Ability to adapt effectively to rapidly approaching deadlines in a dynamic research environment. </li><li>Excellent oral and written communication skills. </li></ul>