<p>How to Apply</p> <p>A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.</p> <p>Job Summary</p> <p>The Genoplastic Surgery Lab (University of Michigan, Section of Plastic Surgery), led by Dr. David Brown, is a basic-translational plastic surgery research laboratory focused on genetic modification of tissues for regenerative medicine, limb loss, and wound healing. Our work sits at the intersection of regenerative biology and gene therapy, using an approach we call genoplastic surgery - A framework for shaping surgical tissues at the molecular level to enable improved repair and regeneration.</p> <p>Our primary model system is mouse digit regeneration, which stands as one of the few examples of complex tissue regeneration in mammals. We study conserved genes and regulatory sequences that control regeneration and leverage them to build gene therapy vectors and regulatory-element-directed expression systems toward the long-term goal of proximal digit and limb regeneration. Additional projects explore gene therapy for other plastic surgery applications, including wound healing and postamputation pain.</p> <p>We are seeking a Research Lab Specialist to serve as the lab's technical anchor and operational leader as the laboratory launches at the University of Michigan (anticipated start on July 1st, 2026). This role is designed for a highly capable experimentalist who can keep the lab running smoothly (compliance, inventory, equipment, mouse colonies) while also contributing scientifically through bench work, data analysis, and co-authorship on publications.</p> <p>Responsibilities*</p> <ul> <li>Serve as day-to-day operational lead for the lab (ordering, inventory, receiving, organization, vendor coordination). </li><li>Maintain regulatory compliance and documentation, coordinate with IACUC, institutional biosafety/IBC, and other EHS/regulatory offices. </li><li>Manage mouse colony logistics (breeding plans, genotyping workflows, recordkeeping, transfers, coordinate specialized services as needed). </li><li>Maintain and troubleshoot core lab equipment, coordinate service contracts, maintain calibration/maintenance logs, and onboarding of new equipment. </li><li>Execute and troubleshoot molecular biology workflows (e.g., PCR/qPCR, cloning, plasmid prep, sample prep for sequencing). </li><li>Support gene delivery workflows (e.g., AAV/plasmid-based studies) consistent with institutional biosafety practices. </li><li>Coordinate and/or perform immunofluorescence and imaging workflows, organize and archive imaging datasets. </li><li>Coordinate NGS experiments with core facilities (e.g., spatial transcriptomics, single-cell RNA-seq, ATAC-seq), ensuring sample integrity and metadata completeness. </li><li>Train and mentor trainees on protocols, safety, recordkeeping, and experimental rigor. </li><li>Contribute to experimental planning, data interpretation, and manuscripts; authorship commensurate with contribution. </li><li>Specific responsibilities may change as the lab grows. </li></ul> <p>Required Qualifications*</p> <ul> <li>Bachelor's degree in a related field and significant progressively responsible laboratory experience (or an equivalent combination of education and experience). </li><li>Strong hands-on experience in molecular biology techniques (e.g., PCR/qPCR, cloning, plasmid work) and quantitative experimental documentation. </li><li>Demonstrated experience working with mice and in a regulated research environment (training/compliance, documentation). </li><li>Proven ability to troubleshoot independently, manage multiple priorities, and communicate effectively with diverse collaborators. </li></ul> <p>Desired Qualifications*</p> <ul> <li>Master's or PhD in a related field and/or publication record. </li><li>Experience with AAV biology/vector workflows and/or other gene delivery approaches. </li><li>Experience with mouse surgical models (or strong interest and ability to learn). </li><li>Experience coordinating/performing NGS workflows (single-cell, spatial, ATAC-seq) and/or downstream analysis. </li><li>Microscopy experience and quantitative image analysis experience. </li><li>Experience building SOPs, inventory systems, and inspection readiness programs. </li></ul> <p>Work Schedule</p> <ul> <li>Full-time (40 hrs/week). </li><li>Laboratory will be located in the Biomedical Sciences Research Building (BSRB) on the University of Michigan Medical Campus. </li><li>Onsite work is expected for most duties (wet lab, animals, imaging). Limited hybrid flexibility may be possible for analysis/writing tasks based on unit policy and operational needs. </li></ul> <p>Modes of Work</p> <p>Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about the work modes</p>