<p>Description</p> <p>Our client is expanding its small molecule research portfolio and seeking a Senior Scientist to serve as a DMPK Project Representative. In this role, you will provide scientific leadership and integrate DMPK strategy to advance drug discovery projects across multiple therapeutic areas. You will collaborate with cross-functional teams, manage outsourced studies, and act as a subject matter expert internally and externally.</p> <p>Key Responsibilities</p> <ul> <li>Serve as the DMPK project representative for global, cross-functional small molecule project teams to achieve project goals. </li><li>Provide expert-level guidance on experimental plans and data interpretation with strong expertise in either ADME/PK/DDI or PK/PD modeling and simulation. </li><li>Troubleshoot highly complex tasks through independent and team-based efforts. </li><li>Demonstrate deep subject matter expertise and creative, independent thinking to address critical scientific questions. </li><li>Make independent decisions related to day-to-day experimental activities. </li><li>Work closely with CROs to oversee DMPK experimental design, implementation, and interpretation. </li><li>Analyze complex data, connect disparate datasets to reach conclusions, and communicate project updates and experimental results to stakeholders. </li><li>Ensure proper documentation of all experiments and data. </li><li>Actively participate in cross-functional teams and meetings to drive project success. </li><li>Share knowledge and expertise to expand team capabilities and promote collaboration. </li><li>Write and review collaborative research manuscripts, project documents, and milestone reports. </li><li>Represent the organization at scientific conferences and global meetings. </li></ul> <p>Skills</p> <ul> <li>Absorption, ADME, PK/PD, metabolism, drug interaction, project management, GMP. </li></ul> <p>Top Skills Details:</p> <p>Absorption, ADME, PK/PD, metabolism, drug interaction.</p> <p>Education & Experience</p> <ul> <li>PhD with ~6-10+ years project-facing experience OR </li><li>Master's with 12+ years OR </li><li>Bachelor's with 18+ years relevant experience. </li></ul> <p>Specialization:</p> <p>Depth in metabolism, biotransformation, or PK/PD modeling (doesn't need to cover all areas).</p> <p>Soft Skills</p> <ul> <li>Strong communicator, collaborative, proactive problem-solver. </li><li>Minimum 3+ years actively participating on discovery project teams (hit-to-lead, lead optimization). </li><li>Ability to distinguish isolated risks vs. project-level risks. </li><li>Comfortable interacting with chemists, pharmacologists, and cross-functional colleagues. </li></ul> <p>Technical Expertise</p> <ul> <li>Deep understanding of absorption, distribution, metabolism, excretion principles. </li><li>Ability to evaluate drug-drug interaction risks, clearance pathways, and biotransformation. </li><li>Experience correlating in vitro potency with in vivo outcomes. </li></ul> <p>Credibility Through Thought Leadership</p> <ul> <li>Publications, abstracts, or posters demonstrating expertise in metabolism, drug interaction, or PK/PD modeling. </li></ul> <p>Experience Level: Expert.Description</p> <p>Our client is expanding its small molecule research portfolio and seeking a Research Scientist to serve as a DMPK Project Representative. In this role, you will provide scientific leadership and integrate DMPK strategy to advance drug discovery projects across multiple therapeutic areas. You will collaborate with cross-functional teams, manage outsourced studies, and act as a subject matter expert internally and externally.</p> <p>Key Responsibilities</p> <ul> <li>Serve as the DMPK project representative for global, cross-functional small molecule project teams to achieve project goals. </li><li>Provide expert-level guidance on experimental plans and data interpretation with strong expertise in either ADME/PK/DDI or PK/PD modeling and simulation. </li><li>Troubleshoot highly complex tasks through independent and team-based efforts. </li><li>Demonstrate deep subject matter expertise and creative, independent thinking to address critical scientific questions. </li><li>Make independent decisions related to day-to-day experimental activities. </li><li>Work closely with CROs to oversee DMPK experimental design, implementation, and interpretation. </li><li>Analyze complex data, connect disparate datasets to reach conclusions, and communicate project updates and experimental results to stakeholders. </li><li>Ensure proper documentation of all experiments and data. </li><li>Actively participate in cross-functional teams and meetings to drive project success. </li><li>Share knowledge and expertise to expand team capabilities and promote collaboration. </li><li>Write and review collaborative research manuscripts, project documents, and milestone reports. </li><li>Represent the organization at scientific conferences and global meetings. </li></ul> <p>Skills</p> <ul> <li>Absorption, ADME, PK/PD, metabolism, drug interaction, project management, GMP. </li></ul> <p>Top Skills Details:</p> <p>Absorption, ADME, PK/PD, metabolism, drug interaction.</p> <p>Education & Experience</p> <ul> <li>PhD with ~6-10+ years project-facing experience OR </li><li>Master's with 12+ years OR </li><li>Bachelor's with 18+ years relevant experience. </li></ul> <p>Specialization:</p> <p>Depth in metabolism, biotransformation, or PK/PD modeling (doesn't need to cover all areas).</p> <p>Soft Skills</p> <ul> <li>Strong communicator, collaborative, proactive problem-solver. </li><li>Minimum 3+ years actively participating on discovery project teams (hit-to-lead, lead optimization). </li><li>Ability to distinguish isolated risks vs. project-level risks. </li><li>Comfortable interacting with chemists, pharmacologists, and cross-functional colleagues. </li></ul> <p>Technical Expertise</p> <ul> <li>Deep understanding of absorption, distribution, metabolism, excretion principles. </li><li>Ability to evaluate drug-drug interaction risks, clearance pathways, and biotransformation. </li><li>Experience correlating in vitro potency with in vivo outcomes. </li></ul> <p>Credibility Through Thought Leadership</p> <ul> <li>Publications, abstracts, or posters demonstrating expertise in metabolism, drug interaction, or PK/PD modeling. </li></ul> <p>Experience Level: Expert.</p> <p>Job Type & Location</p> <p>This is a Contract to Hire position based out of Lexington, MA.</p> <p>Pay and Benefits</p> <p>The pay range for this position is $71.00 - $71.00/hr.</p> <p>Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following: • Medical, dental & vision • Critical Illness, Accident, and Hospital • 401(k) Retirement Plan - Pre-tax and Roth post-tax contributions available • Life Insurance (Voluntary Life & AD&D for the employee and dependents) • Short and long-term disability • Health Spending Account (HSA) • Transportation benefits • Employee Assistance Program • Time Off/Leave (PTO, Vacation or Sick Leave)</p> <p>Workplace Type</p> <p>This is a fully onsite position in Lexington,MA.</p> <p>Application Deadline</p> <p>This position is anticipated to close on Dec 22, 2025.</p> <p>About Actalent</p> <p>Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.</p> <p>The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.</p> <p>If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing due to a disability, please email actalentaccommodation@actalentservices.com for other accommodation options.</p>