<p>About Stoke:</p> <p>Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body's potential with RNA medicine. Using Stoke's proprietary approach, the company is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke's first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights</p> <p>STK-002 is Stoke's proprietary antisense oligonucleotide (ASO) in clinical development for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. STK-002 has been granted orphan drug designation by the FDA. A Phase 1 study (OSPREY) of STK-002 in people with ADOA is now underway. The company is also conducting early research in Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals.</p> <p>Stoke's initial focus is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company's proprietary approach.</p> <p>Position Purpose:</p> <p>Reporting to SVP of Translational DMPK and Clinical Pharmacology, this leadership role will be responsible for providing strategic and scientific leadership for DMPK and biomarker discovery and development to support the programs from early discovery through clinical development.</p> <p>Key Responsibilities:</p> <ul> <li>To ensure that DMPK/ADME and biomarker data inform key decisions to support regulatory submissions. </li><li>Drive the DMPK strategy for new programs and support the functional leads for INDs/CTAs. Oversee related authorship and review of key regulatory documents and engagement with global health authorities. </li><li>Provide thought leadership and decision-making support on IND readiness. </li><li>Collaborate with clinical development team and author and review the relevant sections of IBs, clinical study protocols, CSRs and NDAs/BLAs. </li><li>Contribute on and provide leadership to discovery-stage project teams as a subject matter expert, providing PK and PK/PD input to the design of preclinical studies and predict clinical outcomes. </li><li>Collaborate with R&D team and toxicologist to guide dose selection in preclinical studies, dose/exposure rationale, and safety margins. </li><li>Ensure that appropriate guidance from regulatory agencies is utilized to support GxP work overseen by DMPK team. </li><li>Direct in vitro and in vivo DMPK studies, to enable and inform clinical modeling and translational assessments. </li><li>Lead the integration of biomarker strategies into preclinical and clinical programs to inform drug response, PK/PD modeling and potentially patient stratification. </li><li>Lead integration of bioanalysis, toxicokinetics, and potentially biomarker strategy into nonclinical programs to inform clinical development and regulatory submissions. </li><li>Collaborate with the SMEs and mentor scientists in DMPK team. </li><li>Identify new and manage existing consultants to support DMPK studies. </li><li>Maintain or develop expertise in evolving clinical pharmacology and pharmacometrics approaches. </li><li>Assist in forecasting resources and the department budget. </li><li>Represent the company in external scientific forums, collaborations, and regulatory interactions. </li><li>Excellent communication skills, including the ability to present complex scientific concepts and make actionable recommendations to the team. </li></ul> <p>Required Skills & Experience:</p> <ul> <li>PhD in a scientific discipline with 18+ years of work experience in academia and industry, that is related to drug discovery and development. </li><li>In depth understanding of DMPK and proven track record of leading DMPK strategies. </li><li>Background in developing and implementing biomarker strategies to inform drug development across preclinical and clinical stages is essential. </li><li>Established in leadership role overseeing teams and representing the function to both internal stakeholders. </li><li>Demonstrated track record of advancing oligonucleotide therapeutics-based programs from early discovery through clinical development and regulatory filings. </li><li>Knowledge of FDA/EMA/ICH guidelines to support GxP work in DMPK. </li><li>Experience in overseeing CROs, external consultants, and working with cross-functional program teams. </li><li>Strong leadership, team building, and communication skills; ability to guide functions and levels. </li><li>Experience in working with therapies targeting neurology is desirable. </li></ul> <p>Location(s):</p> <p>Stoke is located in Bedford, MA. This position is a hybrid position with an office setting based in Bedford, MA location.</p> <p>Travel:</p> <p>This position will require approximately 5% travel.</p> <p>Compensation & Benefits:</p> <p>At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program.</p> <p>The anticipated salary range for this role is $330,000 - $365,000. The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation.</p> <p>Our benefits package includes medical, dental and vision insurance; life, long- and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP).</p> <p>Culture & Values:</p> <p>At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual's needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.</p> <p>Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do.</p> <p>Interested candidates: Please visit Stoke's website to learn more and apply directly to the position listed on our Career Center:</p> <p>https://www.stoketherapeutics.com/careers/</p> <p>For more information, visit https://www.stoketherapeutics.com/.</p> <p>All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.</p> <p>Stoke participates in E-Verify.</p>