<p>Overview</p> <p>Monte Rosa Therapeutics is seeking to recruit a highly motivated research associate to join its Proteomics group in Boston to support hit confirmation and drug target validation. This is an exciting opportunity to join a team responsible for identification and validation of novel molecular glue degrader targets. The lab-based position will focus on developing and running cell-based assays to validate hits from the company's proteomics-based screening platform. The candidate should exhibit excellent communication and collaborative skills for working on cross-functional multi-disciplinary drug discovery teams.</p> <p>Responsibilities</p> <ul> <li>Support research efforts discovering and validating small molecule screening hits through development of cellular assays, including target engagement, ternary complex, and degradation assays </li><li>Collaborate with team members to design and execute experiments using routine molecular biology, biochemistry, and cell culture techniques, including working with both immortalized and primary cell lines </li><li>Assay optimization: identification and fine-tuning of critical assay parameters such as optimal gene expression levels, seeding density, timeframe or co-treatments </li><li>Compile and analyze experimental data and communicate research findings at internal meetings </li><li>Prepare and manage laboratory stocks of routinely used reagents </li><li>Accurately document experimental details through timely maintenance of electronic lab notebook records and the development of standard operating procedures (SOPs) for new protocols </li></ul> <p>Qualifications</p> <ul> <li>BSc and/or MSc in Cell Biology, Biochemistry, or a related field, with at least 2 years of relevant industry or academic research experience </li><li>Proficiency in culturing mammalian cells and utilizing sterile techniques (ideally BSL2 standards) </li><li>Hands-on experience with a variety of cell culture and cellular biochemistry techniques, including at least several of the following: transfection, lentiviral transduction, cell line generation, cell viability assays, SDS-PAGE/Western blot, immunoprecipitation/co-IP, and flow cytometry </li><li>Experience with cellular PPI, target engagement, ternary complex or degradation assays is preferred </li><li>Critical and independent thinking, strong analytical and problem-solving skills </li><li>Highly collaborative and able to work in a matrix, interactive, and fast-paced drug discovery environment. </li><li>Excellent oral and written communication skills to work in a collaborative, matrix team </li></ul>