<p>About the Job</p> <p>This position is in a laboratory of Dr. Michael Lee who is interested defining the</p> <p>pathologic mechanisms for Alzheimer's Disease (AD) and Parkinson's Disease (PD)</p> <p>using cellular and transgenic mouse models. The candidate will assist the Principal</p> <p>Investigator by performing duties related to characterizing neuropathology in animal</p> <p>models.</p> <p>(45% effort) Perform histological analysis of mouse brain. Perform euthanasia and</p> <p>fixation of mouse brain. Prepare fixed brain for frozen or paraffin sections. Perform</p> <p>paraffin embedding of tissues and generate paraffin sections. Generate frozen sections</p> <p>on sliding microtome for stereological analysis. Perform histochemical and</p> <p>immunohistochemical analysis. Generate sections for RNA based analysis</p> <p>(RNAscope, GoeMx, CosMx) and perform simple RNAscope procedures.</p> <p>(30 % effort) Perform imagine and quantitative analysis of stained sections.</p> <p>Perform whole slide scanning using Motic Slide Scanner of stained slides for analysis.</p> <p>Learn and perform quantitative analysis of stained slides using Image J and/or HALO</p> <p>image analysis system. Learn and perform quantitative analysis using Microbrightfield</p> <p>Stereology system. Image immunofluorescence sections via widefield</p> <p>immunofluorescence or confocal microscopy.</p> <p>(20 % effort) Maintain histology infrastructure. Regular maintenance of paraffin</p> <p>processing/embedding equipment. Ensure that required service contracts and software</p> <p>licenses need for histological studies are up to date. Work with vendors to trouble shoot</p> <p>any problems with the software and/or equipment. Arrange for any service if needed.</p> <p>Train new staff on the proper histological/immunohistochemical techniques and the</p> <p>proper use of equipment.</p> <p>(5% effort) Prepare weekly progress to present at weekly lab meetings.</p> <p>Qualifications</p> <p>All required qualifications must be included in the application materials</p> <p>Required Qualifications:</p> <ul> <li>Bachelor's degree in Neuroscience or related field (e.g. Biology, Psychology) plus at least two years of relevant experience, or a combination of related education and work experience to equal at least six years. </li><li>Previous experience work with mice </li><li>Must be willing to work with mouse model of Alzheimer's disease and Parkinson's Disease. </li></ul> <p>Preferred Qualifications:</p> <ul> <li>Certification in scientific or medical histology. </li><li>Prior experience in histological analysis, particularly rodent brains. </li><li>Familiarity with Alzheimer's or Parkinson's disease </li></ul> <p>About the Department</p> <p>The Department of Neuroscience is committed to providing excellence in research, education, and public service. The Department of Neuroscience is part of the University of Minnesota's Medical School. The Medical School and related healthcare professional schools are grouped under the Academic Health Center.</p> <p>The Mission of the Department of Neuroscience</p> <ul> <li>Conduct outstanding neuroscience research. </li><li>Be an educational resource to the Medical School and the University by providing neuroscience education to undergraduate, medical, dental, graduate, and post-graduate students. </li><li>Provide leadership and be a focal point for the strengthening of neuroscience across the University by enhancing research, educational, and funding opportunities. </li><li>Intentionally improve inclusivity by valuing diverse perspectives and actively supporting historically marginalized researchers, students, and neuroscience community members. </li><li>Provide a bridge for the transfer of advances in basic neuroscience into clinical practice with the goal of improving the health of the people of Minnesota. </li></ul> <p>Enhance the understanding and appreciation of neuroscience by the people of Minnesota</p> <p>Pay and Benefits</p> <p>Pay Range: $23.00 to $27.00/hour; depending on education/qualifications/experience</p> <p>Time Appointment Category: 75%-100% Appointment (If job description above does not specify appointment or expected weekly hours, assume a 100% appointment.)</p> <p>Position Type: Civil-Service & Non-Faculty Labor Represented Staff</p> <p>Please visit the Office of Human Resources website for more information regarding benefit eligibility.</p> <p>The University offers a comprehensive benefits package that includes:</p> <ul> <li>Competitive wages, paid holidays, and generous time off </li><li>Continuous learning opportunities through professional training and degree-seeking programs supported by the Regents Tuition Benefit Program </li><li>Low-cost medical, dental, and pharmacy plans </li><li>Healthcare and dependent care flexible spending accounts </li><li>University HSA contributions </li><li>Disability and employer-paid life insurance </li><li>Employee wellbeing program </li><li>Excellent retirement plans with employer contribution </li><li>Public Service Loan Forgiveness (PSLF) opportunity </li><li>Financial counseling services </li><li>Employee Assistance Program with eight sessions of counseling at no cost </li><li>Employee Transit Pass with free or reduced rates in the Twin Cities metro area </li></ul> <p>How To Apply</p> <p>Applications must be submitted online. To be considered for this position, please click the Apply button and follow the instructions. You will be given the opportunity to complete an online application for the position and attach a cover letter and resume.</p> <p>Additional documents may be attached after application by accessing your "My Job Applications" page and uploading documents in the "My Cover Letters and Attachments" section.</p> <p>To request an accommodation during the application process, please e-mail employ@umn.edu or call (612) 624-8647.</p> <p>Diversity</p> <p>The University recognizes and values the importance of diversity and inclusion in enriching the employment experience of its employees and in supporting the academic mission. The University is committed to attracting and retaining employees with varying identities and backgrounds.</p> <p>The University of Minnesota provides equal access to and opportunity in its programs, facilities, and employment without regard to race, color, creed, religion, national origin, gender, age, marital status, disability, public assistance status, veteran status, sexual orientation, gender identity, or gender expression. To learn more about diversity at the U: http://diversity.umn.edu</p> <p>Employment Requirements</p> <p>Any offer of employment is contingent upon the successful completion of a background check. Our presumption is that prospective employees are eligible to work here. Criminal convictions do not automatically disqualify finalists from employment.</p> <p>About the U of M</p> <p>The University of Minnesota, Twin Cities (UMTC)</p> <p>The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation's most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations.</p> <p>At the University of Minnesota, we are proud to be recognized by the Star Tribune as a Top Workplace for 2021, as well as by Forbes as Best Employers for Women and one of America's Best Employers (2015, 2018, 2019, 2023), Best Employer for Diversity (2019, 2020), Best Employer for New Grads (2018, 2019), and Best Employer by State (2019, 2022).</p>