<p>The Position</p> <p>We are seeking a Chemist to join the Development Chemistry Group focusing on oligonucleotide synthesis development. This is an ideal position for an individual with an organic or biological chemistry background who has an interest in projects related to novel technology in synthesis and purification of oligonucleotides and bioconjugates.</p> <p>Responsibilities</p> <ul> <li>Work closely with senior chemists on development of new synthetic approaches to desired compounds with an eye toward large-scale synthesis </li><li>Cooperate with other chemists in the group in preparation of complex organic constructs </li><li>Perform solid-phase synthesis and purification of oligonucleotide drug candidates </li><li>Analyze small-molecule and macromolecular targets using standard methods </li><li>Maintain a well-documented laboratory notebook </li><li>Prepare documentation for transfer of new technologies to the Manufacturing group </li><li>Track progress against project timelines, generate regular status updates, and communicate progress and issues to management, including presentation of findings at team meetings </li><li>Coordinate delivery of materials both internally and externally </li></ul> <p>Requirements:</p> <ul> <li>BS or MS in chemistry or biochemistry with an excellent understanding of organic and analytical chemistry </li><li>Excellent verbal and written communication skills </li><li>Strong problem-solving skills </li><li>Eagerness to learn new techniques </li><li>Experience with synthetic organic chemistry in a laboratory setting </li><li>Experience with small-molecule and macromolecule analytical techniques (e.g., HPLC, UV-Vis spectrophotometry, mass spectrometry, NMR, etc.) </li></ul> <p>Preferred:</p> <ul> <li>Experience working with both small molecule or large molecule synthetic targets either in an academic or industrial setting </li><li>Experience with solid phase synthesis of oligonucleotides or peptides </li><li>Basic familiarity with GLP/GMP regulations </li></ul>